Effects of an NMDA-receptor antagonist MK-801 on an MMN-like response recorded in anesthetized rats
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- 作者：Dmitry Tikhonravov ; Tuomas Neuvonen ; Antti Pertovaara ; Kati Savioja ; Timo Ruusuvirta ; Risto Nä ; ä ; tä ; nen ; Synnö ; ve Carlson
- 关键词：MK-801 ; Mismatch negativity (MMN) ; Oddball paradigm ; Rat
- 刊名：Brain Research
- 出版年：2008
- 出版时间：8 April 2008
- 年：2008
- 卷：1203
- 期：Complete
- 页码：97-102
- 全文大小：336 K
文摘
In the human brain, auditory sensory memory has been extensively studied using a well-defined component of event-related potential named the mismatch negativity (MMN). The MMN is generated in the auditory and frontal cortices in response to deviant stimuli. In monkeys, cortical N-methyl-d-aspartate (NMDA) receptors have a central role in the generation of the MMN. MMN-like responses have also been recorded in other animals, including rats. The present study aimed at determining whether the MMN-like response in rats depends on an intact NMDA-receptor system. We recorded auditory evoked responses during an oddball paradigm epidurally in anesthetized rats that had received intraperitoneal injections of saline or an NMDA-receptor antagonist MK-801. An MMN-like response was recorded in the oddball paradigm in saline-treated rats. Further, this response was dose-dependently blocked by MK-801. These results suggest that the MMN-like response in rats depends on an intact NMDA-receptor system.