Soluble Fas/FasL ratio as a marker of vasculopathy in children and adolescents with sickle cell disease

详细信息    查看全文

• 作者：Amira A. Adly^a ; Eman A. Ismail^b ; ^{eman.ismail_70@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Nevine G. Andrawes^a ; Mai M. Mahmoud^a ; Rasha Eladawy^a
• 关键词：Fas/FasL ; Sickle cell disease ; Inflammation ; Nephropathy ; Pulmonary hypertension ; Hydroxyurea therapy
• 刊名：Cytokine
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：79
• 期：Complete
• 页码：52-58
• 全文大小：594 K

文摘

<dl class="listitem" id="list_l0005"><dt class="label">•dt><dd>

d="p0005">We determined sFas/sFasL ratio in young patients with SCD.

dd><dt class="label">•dt><dd>

d="p0010">sFas/sFasL was elevated in patients with nephropathy or pulmonary hypertension.

dd><dt class="label">•dt><dd>

d="p0015">sFas/sFasL was increased in patients with frequent sickling crisis.

dd><dt class="label">•dt><dd>

d="p0020">sFas/sFasL levels were related to inflammation, iron overload and albuminuria level.

dd><dt class="label">•dt><dd>

d="p0025">SCD patients treated with hydroxyurea had lower sFas/sFasL ratio.

dd>dl>