- 作者：Ragaa Mansour ; M.D. ; Ph.D. ; ragaa.mansour@gmail.com ; Nevine Tawab ; B.Sc. ; Omnia Kamal ; B.Biomed. ; Yahia El-Faissal ; M.D. ; Ahmed Serour ; M.D. ; Mohamed Aboulghar ; M.D. ; Gamal Serour ; M.D.
- 关键词：hCG ; ICSI ; implantation rate ; intrauterine hCG ; IVF ; pregnancy rate
- 刊名：Fertility and Sterility
- 出版年：2011
- 出版时间：December, 2011
- 年：2011
- 卷：96
- 期：6
- 页码：1370-1374.e1
- 全文大小：424 K
Objective
To investigate the value of intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer (ET).Design
Prospective randomized study.
Setting
The Egyptian IVF-ET Center.
Patient(s)
Infertility patients younger than 40 years undergoing their first in?vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI).
Intervention(s)
The study group (n = 167) received either 100 IU of hCG (n = 83), or 200 IU of hCG (n = 84) via intrauterine administration before ET. The control group (n = 93) underwent ET without hCG. After the interim analysis, the modified study group (n = 107) received intrauterine injection of 500 IU of hCG, and the control group (n = 105) underwent ET without hCG.
Main Outcome Measure(s)
Clinical pregnancy rate (PR) and implantation rate (IR).
Result(s)
The IR and PR were statistically significantly higher in the 500 hCG group (41.6 % and 75 % , respectively) as compared with the control group (29.5 % and 60 % , respectively). The IR and PR were 26.6 % and 54 % in the 100 hCG group, 28.3 % and 57 % in the 200 IU hCG group, and 29.4 % and 60 % in the control group, respectively, with no statistically significant difference.
Conclusion(s)
Intrauterine injection of 500 IU of hCG before ET statistically significantly improved the implantation and pregnancy rates in IVF/ICSI.
Clinical trials.gov number
NCT 01030393.