Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity
详细信息 查看全文
- 作者：Dane M. Newman
- 关键词：T cells ; virus ; memory ; histone acetylation ; epigenetic
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：20 September 2016
- 年：2016
- 卷：16
- 期：12
- 页码：3311-3321
- 全文大小：2177 K
文摘
- •
- <p id="p0010">Loss of KAT6A during viral infection results in reduced cell surface CD8 and TCR levelsp>
- •
- <p id="p0015">KAT6A acetylates histones of the Cd8 locus, specifically, the promoter and E8I enhancerp>
- •
- <p id="p0020">KAT6A deficiency results in reduced effector-like memory CD8
- •
- <p id="p0025">Removal of the Cd8 E8I enhancer phenocopies KAT6A removalp>