• 作者：Antonia Garcí ; a-Martí ; n^a ; ^{garciamartin_t@hotmail.com} ; Miguel Quesada Charneco^a ; Alejandro Alvá ; rez Guisado^a ; Jos&#233 ; Juan Jim&#233 ; nez Moleó ; n^b ; Juristo Fonollá ; Joya^c ; Manuel Muñ ; oz-Torres^a
• 关键词：Isoflavonas ; Soja ; Calidad de vida ; Metabolismo ó ; seo ; Posmenopausia
• 刊名：Medicina Cl¡§anica
• 出版年：2012
• 出版时间：4 February, 2012
• 年：2012
• 卷：138
• 期：2
• 页码：47-51
• 全文大小：235 K

Background and objective

To analyze the effects of nutritional intervention with a milk product enriched with soy isoflavones on quality of life and bone metabolism in postmenopausal Spanish women.

Patients and method

We performed a double-blind controlled randomized trial in ninety-nine postmenopausal women. Group S women (n = 48) were randomized to consume milk product enriched with soy isoflavone (50 mg/day) while group C (n = 51) consumed product control for 12 months. Parameters of quality of life (Cervantes scale), markers of bone metabolism and bone mass estimated by ultrasound of the calcaneus (QUS) were evaluated.

Results

Overall, there was an improvement in the domains menopause (P = .015) and vasomotor symptoms (P < .001). S group emphasized the assessment of vasomotor symptoms (P = .001) and differed positively from group C in health (P = .019), sex (P = .021) and partner (P = .002). Serum levels TRAP (P < .001) and OPG (P = .007) decreased and concentrations of 25-OH-vitamin D increased (P < .001) without differences between groups. In the assessment of QUS, there was an increase in estimated bone mineral density in group S (P = .040), whereas in group C there were no significant differences.

Conclusions

Daily consumption of these milk products increases levels of 25-OH-vitamin D and decreases bone metabolism markers. Additional supplementation with soy isoflavones seems to improve quality of life and bone mass in Spanish postmenopausal women.