Superoxide anion-induced pain and inflammation depends on TNF伪/TNFR1 signaling in mice
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- 作者：Fabiane Y. Yamacita-Borina ; c ; Ana C. Zarpelona ; Felipe A. Pinho-Ribeiroa ; Victor Fattoria ; Jose C. Alves-Filhob ; Fernando Q. Cunhab ; Thiago M. Cunhab ; Rubia Casagrandec ; Waldiceu A. Verri Jr.a ; waverri@uel.br" class="auth_mail" title="E-mail the corresponding author ; waldiceujr@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hyperalgesia ; Inflammation ; Oxidative stress ; Superoxide anion ; TNF伪 ; TNFR1
- 刊名：Neuroscience Letters
- 出版年：2015
- 出版时间：25 September 2015
- 年：2015
- 卷：605
- 期：Complete
- 页码：53-58
- 全文大小：1101 K
文摘
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Superoxide anion induces pain and inflammation.
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Targeting TNF伪/TNFR1 signaling reduces superoxide anion-induced pain/ inflammation.
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TNF伪/TNFR1 signaling mediates superoxide anion-induced oxidative stress.
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Inhibiting NADPH oxidase and SOD mimicry reduce TNF伪-induced pain and inflammation.
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Superoxide anion-induced pain and inflammation depends on TNF伪/TNFR1 signaling.