NF魏B- and AP-1-mediated DNA looping regulates matrix metalloproteinase-9 transcription in TNF-伪-treated human leukemia U937 cells
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- 作者：Ying-Jung Chena ; Long-Sen Changa ; b ; lschang@mail.nsysu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：MMP-9 ; DNA looping ; TNF-伪 ; NF魏B/p65 ; AP-1/c-Jun ; Histone acetylation
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：1849
- 期：10
- 页码：1248-1259
- 全文大小：1637 K
文摘
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NFkB/AP-1-mediated DNA looping is involved in TNF-伪-induced MMP-9 up-regulation.
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TNF-伪 reduces HDAC-1 but increases p300 recruitment to MMP-9 promoter regions.
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Histone acetylation increases the level of NFkB/AP-1-mediated DNA looping.
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Histone deacetylation reduces the level of NFkB/AP-1-mediated DNA looping.
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Reduction in the level of DNA looping abolishes TNF-伪-induced MMP-9 up-regulation.