Nuclear factor of activated T-cells (NFAT) regulates soluble fms-like tyrosine kinase-1 secretion (sFlt-1) from human placenta
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- 作者：Louie Yea ; Amy Grattona ; Natalie J. Hannana ; Ping Cannona ; Minh Deoa ; Kirsten R. Palmerb ; Stephen Tonga ; Tu'uhevaha J. Kaitu'u-Linoa ; 1 ; t.klino@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author ; Fiona C. Brownfoota ; 1
- 关键词：Preeclampsia ; NFAT ; sFlt-1 ; Hypoxia
- 刊名：Placenta
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：48
- 期：Complete
- 页码：110-118
- 全文大小：2109 K
文摘
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Inhibiting NFAT reduces placental sFlt-1 transcription and secretion.
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Inhibiting NFAT reduces placental cytokine transcription.
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Placental NFAT1 and NFAT3 are reduced under hypoxia.
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NFAT1-4 mRNA is not dysregulated in preeclamptic placenta.