Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals
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- 作者：Pulak Kar1 ; Gary R. Mirams2 ; Helen C. Christian1 ; Anant B. Parekh1 ; 3 ; anant.parekh@dpag.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：17 November 2016
- 年：2016
- 卷：64
- 期：4
- 页码：746-759
- 全文大小：4344 K
文摘
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NFAT1 is activated by local Ca2+ entry, whereas NFAT4 also needs nuclear Ca2+
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Nuclear Ca2+ increases via InsP3 receptors located on the inner nuclear membrane
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NFAT1 and NFAT4 show very different rephosphorylation (deactivation) kinetics
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Slow deactivation of NFAT1 affords a form of short-term memory to gene expression