Increased immunosuppressive function of CD4⁺CD25⁺Foxp3⁺GITR+ T regulatory cells from NFATc2^(?/?) mice controls allergen-induced experimental asthma

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• 作者：Roman Karwot ; Caroline ¨¹bel ; Tobias Bopp ; Edgar Schmitt ; Susetta Finotto
• 关键词：AHR ; airway hyperresponsiveness ; BAL ; bronchoalveolar lavage ; BALF ; BAL fluid ; MCh ; methacholine ; N ; normal (concentration of ionizable groups) ; qPCR ; quantitative real-time polymerase chain reaction ; Ri ; airway resistance ; t test ; Student's t test
• 刊名：Immunobiology
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：217
• 期：9
• 页码：905-911
• 全文大小：678 K

文摘

The expansion of effector T cells is tightly controlled by transcription factors like nuclear factor of activated T cells (NFAT) family members that mediate early intracellular responses to T cell receptor-mediated signals. In this study we show that, after allergen challenge, NFATc2^(?/?) mice had augmented number of functionally intact CD4⁺CD25⁺⁺GITR⁺⁺ T regulatory (T regs) cells in the lung. Anti-GITR antibody treatment inhibited T regulatory cell function and enhanced the number of activated lung CD4⁺ T cells associated with increased IL-2 and pSTAT-5 in the airways of NFATc2^(?/?) mice in experimental allergic asthma. This agonistic treatment led to increased inflammation in the lung of NFATc2^(?/?) treated mice. These data indicate that NFATc2^(?/?) mice have increased number of CD4⁺CD25⁺Foxp3⁺ T regulatory cells with induced immunosuppressive function that control allergen-induced experimental asthma.