Comprehensive assessment of lipoprotein subfraction profiles according to glucose metabolism status, and association with insulin resistance in subjects with early-stage impaired glucose metabolism

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• 作者：Jie-Eun Lee^a ; Se Hee Min^a ; Dong-Hwa Lee^a ; Tae Jung Oh^a ; Kyoung Min Kim^a ; Jae Hoon Moon^a ; Sung Hee Choi^a ; Kyong Soo Park^b ; Hak Chul Jang^a ; Soo Lim^a ; ^{limsoo@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Atherogenic dyslipidemia ; Lipoprotein subfraction profile ; Small dense low-density lipoprotein ; Glucose metabolism ; Impaired fasting glucose
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：225
• 期：Complete
• 页码：327-331
• 全文大小：347 K

文摘

Early detection of atherogenic dyslipidemia is crucial. We investigated lipoprotein subfraction parameters according to glucose metabolism status.

Methods

We recruited 1255 lipid-lowering drug-naïve subjects with normal fasting glucose (NFG; n = 200, 15.9%), impaired fasting glucose (IFG; n = 443, 35.3%), or type 2 diabetes (T2D; n = 612, 48.8%). Lipoprotein subfractions (1–7) were determined by polyacrylamide gel electrophoresis, separating low-density lipoprotein (LDL) into large buoyant LDL (lbLDL, LDL1–2) and small dense LDL (sdLDL, LDL3–7). Lipoprotein subfraction parameters including the sdLDL% (LDL3–7/LDL1–7), the sdLDL/lbLDL ratio (LDL3–7/LDL1–2), and weighted LDL subfraction (LDLSF) scores, were compared between groups. Their associations with insulin resistance, estimated using the homeostasis model assessment of insulin resistance, were examined.

Results

The concentrations of sdLDL particles were significantly higher in subjects with T2D and IFG than in those with NFG (15.78 ± 13.47 mg/dl and 14.60 ± 14.33 mg/dl, respectively, vs. 12.22 ± 12.31 mg/dl). Compared with those with NFG, subjects with IFG or T2D had significantly a higher sdLDL% (15.98 ± 15.26% vs. 19.50 ± 16.21% or 21.46 ± 16.81%, respectively), a higher sdLDL/lbLDL ratio (0.24 ± 0.30 vs. 0.31 ± 0.37 or 0.35 ± 0.39), and a higher LDLSF score (2.08 ± 0.91 vs. 2.30 ± 1.14 or 2.36 ± 1.17). These lipoprotein subfraction parameters had stronger associations with insulin resistance compared to conventional lipid profiles in the IFG and T2D groups.

Conclusions

Atherogenic dyslipidemia is initiated in an early stage of impaired glucose metabolism, when early intervention might be required.