Rewiring the Pneumococcal Cell Cycle with Serine/Threonine- and Tyrosine-kinases

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• 作者：Christophe Grangeasse¹ ; ^{c.grangeasse@ibcp.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：cell division ; cell morphogenesis ; protein phosphorylation ; polysaccharide capsule biosynthesis and export ; bacterial cell cycle ; Streptococcus pneumoniae
• 刊名：Trends in Microbiology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：24
• 期：9
• 页码：713-724
• 全文大小：2483 K

文摘

Over the past decade, Streptococcus pneumoniae (the pneumococcus) has gained prominence as a model for studying the bacterial cell cycle. This important human pathogen possesses a characteristic diplo-ovococcal cell shape and produces a protective polysaccharide capsule required for virulence, and it has been used to investigate natural genetic transformation. Recent advances have demonstrated that the pneumococcus has evolved phosphorylation-dependent regulatory mechanisms dedicated to controlling cell division and ensuring the concealment of the newborn cells by the capsule. In this review, I survey the role of the only two serine/threonine- (StkP) and tyrosine-kinases (CpsD) of the pneumococcus and discuss the existence of interconnected phosphorylation networks coordinating cell division and morphogenesis with key aspects of the cell cycle.