Imidazolium ionic liquid triggers phase segregation in surfactants aqueous solutions.
Tie-line and solubility data were suitably correlated with empirical models.
Ionic liquid concentration in feed phase drastically changed clenbuterol partition.
Ethynylestradiol was almost completely segregated to the surfactant-rich phase.
Clenbuterol and ethynylestradiol selective separation was proved in synthetic urine.