Decreased circadian component Bmal1 predicts tumor progression and poor prognosis in human pancreatic ductal adenocarcinoma
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- 作者：Wenhua Lia ; 1 ; lwh42558@sina.com" class="auth_mail" title="E-mail the corresponding author ; Ling Liua ; 1 ; linger3307@126.com" class="auth_mail" title="E-mail the corresponding author ; Di Liua ; 1 ; luddy8891@sina.com" class="auth_mail" title="E-mail the corresponding author ; Shimao Jina ; jinshimao85@sina.com" class="auth_mail" title="E-mail the corresponding author ; Yisha Yanga ; yangyisha0503@126.com" class="auth_mail" title="E-mail the corresponding author ; Wei Tangb ; 13771067011@163.com" class="auth_mail" title="E-mail the corresponding author ; Lei Gonga ; gonglei0520@yahoo.com.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Circadian clock ; Bmal1 ; Pancreatic ductal adenocarcinoma ; Prognosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：25 March 2016
- 年：2016
- 卷：472
- 期：1
- 页码：156-162
- 全文大小：2968 K
文摘
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The expression of Bmal1 is decreased in human pancreatic ductal adenocarcinoma (PDA).
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Decreased Bmal1 expression correlates with advanced TNM stage and poor histological differentiation of PDA.
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Low Bmal1 expression is an independent prognostic factor for poor survival outcome for patients with PDA.