We performed a prospective monocentric study including 50 consecutive patients with stable coronary artery disease treated by aspirin (75 to 250 mg/day) without any other antiaggregant treatment. Aspirin resistance was characterized 24 hours after aspirin intake by light transmission aggregometry using 0.5 mg/mL arachidonic acid. Aspirin resistance was defined as >20 % residual agregation. Platelet turn-over was estimated at the same time by measurement of mean platelet volume, % of reticulated platelets, serum P-selectin, platelet P-selectin and serum thrombopoietin.
Among 50 patients (70 ¡À 11 y.o. mean ¡À 1,5, 76 % male, 52 % type 2 diabetes mellitus, 16 % active smokers), 18 (36 % ) were identified as aspirin resistants. Table 1 shows the mean value of markers currently linked to platelet turn-over depending on the presence of aspirin resistance. Serum thrombopoietin was significantly increased in patients with aspirin resistance compared to patients with no aspirin resistance. No statistical difference was demonstrated for mean platelet volume, reticulated platelets, platelet P-selectin and serum P-selectin. Serum thrombopoietin values were not correlated with other platelet turn-over parameters. There was no significant correlation between serum thrombopoietin and inflammatory markers.
Aspirin sensitive | Aspirin resistant | p | |
---|---|---|---|
Platelet volume (fl) | 8.78 ¡À 0.26 | 8.82 ¡À 0.30 | 0.92 |
Reticulated platelet ( % ) | 8.4 ¡À 0.52 | 8.6 ¡À 0.76 | 0.82 |
Serup P selectin (ng/ml) | 42.6 ¡À 4.29 | 42.9 ¡À 4.75 | 0.97 |
Platelet P selectin ( % ) | 11.1 ¡À 1.0 | 9.5 ¡À 1.5 | 0.35 |
Serum thrombopoietin (pg/ml) | 130.6 ¡À 11.3 | 319.9 ¡À 97.8 | 0.01 |