Neurotrophic factors and their inhibitors in chronic pain treatment

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• 作者：Jayne H. Kelleher ; ^{jayne.kelleher@kcl.ac.uk} ; Damini Tewari ; Stephen B. McMahon
• 关键词：NGF ; IL6 ; Pain ; Clinical trial
• 刊名：Neurobiology of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：97
• 期：part_PB
• 页码：127-138
• 全文大小：1200 K
• 卷排序：97

文摘

Chronic pain affects more than 20% of the UK population. Neurotrophic factors have been identified as therapeutic targets to improve current treatments of chronic pain. This review article focuses on nerve growth factor (NGF) and interleukin-6 (IL-6) as potential therapeutic targets. In this review we highlight the mechanisms of action and the current progress of targeted therapies in clinical trials.