Side chain alkynyldipeptides derived from Gly, Cys and Lys were prepared.
Both alkynes were coordinated to tungsten to generate metallacyclicdipeptides.
Conformational mobility of the metallacyclicdipeptides was probed using VT-NMR.
The two largest metallacycles adopt multiple, equilibrating conformations.
The smallest metallacycle adopts multiple, but non-equilibrating, conformations.