Sodium/proton exchanger isoform 1 regulates intracellular pH and cell proliferation in human ovarian cancer

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• 作者：Carlos Sanhueza^a ; ^{csanhuezamunoz@gmail.com} ; Joaquí ; n Araos^a ; Luciano Naranjo^a ; Fernando Toledo^a ; ^b ; Ana R Beltrá ; n^c ; ^d ; Marco A Ramí ; rez^a ; ^d ; Jaime Gutié ; rrez^a ; ^e ; Fabiá ; n Pardo^a ; ^f ; Andrea Leiva^a ; Luis Sobrevia^a ; ^g ; ^h ; ^{sobrevia@med.puc.cl}
• 关键词：NHE1 ; pHi ; Human ; Ovarian cancer ; Cell proliferation
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：81-91
• 全文大小：1470 K
• 卷排序：1863

文摘

Human ovary tissue expresses functional Na+/H+ exchanger 1 (NHE1) isoform. Expression of NHE1 is increased in human ovarian tumour epithelial cells. NHE1 regulates intracellular pH in human ovarian tumour cells. NHE1 activity is a pro-proliferative factor in human ovarian tumour cells. High NHE1 expression and activity associate with lower overall patients' survival