Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism
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- 作者：Jorge C. Correia1 ; 2 ; Julie Massart3 ; Jan Freark de Boer4 ; Margareta Porsmyr-Palmertz1 ; Vicente Martí ; nez-Redondo1 ; Leandro Z. Agudelo1 ; Indranil Sinha5 ; David Meierhofer6 ; Vera Ribeiro2 ; Marie Bjö ; rnholm3 ; Sascha Sauer6 ; Karin Dahlman-Wright5 ; Juleen R. Zierath3 ; Albert K. Groen4 ; Jorge L. Ruas1 ; jorge.ruas@ki.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：FXR isoforms ; Splicing ; NAFLD ; Insulin resistance ; Energy metabolism
- 刊名：Molecular Metabolism
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：4
- 期：12
- 页码：891-902
- 全文大小：3332 K
文摘
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FXR variants regulate discrete gene programs with distinct biological outcomes.
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FXRα2 (but not α1) enhances fatty acid handling and insulin responsiveness.
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FXRα1 and α2 reduce liver lipid content through different mechanisms.
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Fasting and physical exercise dynamically regulate Fxr splicing in liver.