Single molecule force measurements of perlecan/HSPG2: A key component of the osteocyte pericellular matrix
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- 作者：Sithara S. Wijeratnea ; 1 ; Jerahme R. Martinezb ; 1 ; Brian J. Grindelb ; Eric W. Freya ; Jingqiang Lia ; Liyun Wangd ; Mary C. Farach-Carsonb ; c ; farachca@rice.edu" class="auth_mail" title="E-mail the corresponding author ; Ching-Hwa Kianga ; c
- 关键词：Perlecan ; Heparan sulfate proteoglycan ; Atomic force microscopy ; Osteocytes ; Lacunar canalicular system ; Bone
- 刊名：Matrix Biology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：50
- 期：Complete
- 页码：27-38
- 全文大小：1032 K
文摘
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Perlecan is large enough to span the pericellular fluid annulus in cortical bone.
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Perlecan withstands forces higher than expected in physiological conditions.
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Perlecan functions as a flexible-rod like tether.
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Disulfide linkages stabilize the domain structure of perlecan and prevent unfolding.