α3β4 nicotinic receptors in the medial habenula and substance P transmission in the interpeduncular nucleus modulate nicotine sensitization
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- 作者：Branden L. Eggan Egganb@mail.amc.edu" class="auth_mail" title="E-mail the corresponding author ; Sarah E. McCallum ; Mccalls@mail.amc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：α-Conotoxin AuIB ; Ezlopitant ; Medial habenula ; Interpeduncular nucleus ; α3β4 nicotinic acetylcholine receptor ; Substance P receptor ; Nicotine ; Sensitization ; Microdialysis ; Locomotor activity
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：94-103
- 全文大小：2006 K
文摘
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Behavioral and neurochemical sensitization develops after five days of nicotine exposure.
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α3β4 nAChR blockade in the MHb blocks sensitized responding to nicotine.
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Substance P receptor blockade in the IPN blocks sensitized responding to nicotine.
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The MHb and IPN differentially modulate the effects of nicotine, in vivo..