Anti-Saccharomyces cerevisiae antibodies (ASCA) in spondyloarthritis: Prevalence and associated phenotype

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• 作者：Jé ; ré ; my Maillet^a ; ^b ; ^{philippe.dieude@bch.aphp.fr" class="auth_mail" title="E-mail the corresponding author} ; Sé ; bastien Ottaviani^a ; ^b ; Florence Tubach^b ; ^c ; Carine Roy^b ; ^c ; Pascale Nicaise-Rolland^b ; ^d ; Elisabeth Palazzo^a ; ^b ; Philippe Dieudé ; ^a ; ^b
• 关键词：ASCA ; Spondyloarthritis ; Phenotype
• 刊名：Joint Bone Spine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：83
• 期：6
• 页码：665-668
• 全文大小：354 K

文摘

The aim of the study was to compare the prevalence of ASCA in spondyloarthrites (SpA) patients and to investigate the association between ASCA status and disease phenotype.

Methods

We performed a case-control study including SpA individuals fulfilling the ESSG SpA criteria. The following data were collected for analysis: gender, age, disease duration, clinical or associated features of SpA, treatments, HLAB27 and ASCA status. A control group of patients without SpA was also analyzed.

Results

A total of 235 patients with SpA and 54 control patients were studied. The median age of SpA patients (53.6% of male patients, 52.2% of HLAB27) was 46.0 [IQR 35.0–57.0] years old. Disease duration was 60.0 [IQR 24.0–156.0] months. Inflammatory bowel diseases were observed in 11% of SpA patients. ASCA positivity was significantly higher in SpA patients than in control patients (25.5% [95% CI 20.1–31.6] (IgG: 9.8%; IgA: 21.7%) vs. 7.4% [95% CI 2.1–17.9], P = 0.004). Multivariate analysis revealed that ASCA positivity was associated with peripheral involvement (OR: 3.30 [1.26–8.62], P = 0.015), presence of IBD (OR: 3.43 [1.15–10.20], P = 0.026), past of present history of uveitis (OR: 4.36 [1.08–17.64], P = 0.039) and arthritis (OR: 3.78 [1.57–9.15], P = 0.003).

Conclusion

Our results provided evidence that SpA patients had an increased prevalence of ASCA and that ASCA positivity might be associated with a particular phenotype, notably peripheral involvement and uveitis.