Patterns of microstructural white matter abnormalities and their impact on cognitive dysfunction in the various phases of type I bipolar disorder
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- 作者：Paola Magioncaldaa ; 1 ; paola.magioncalda@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Matteo Martinoa ; 1 ; matteomartino9@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Benedetta Conioa ; benedetta.conio@hotmail.it" class="auth_mail" title="E-mail the corresponding author ; Niccolò ; Piaggiob ; aaa_sj86@yahoo.it" class="auth_mail" title="E-mail the corresponding author ; Roxana Teodorescuc ; roxana.oana@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Andrea Escelsiora ; andrea.escelsior@live.com" class="auth_mail" title="E-mail the corresponding author ; Valentina Marozzia ; valeviaggia@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Giulio Rocchia ; giulio.rocchi@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Luca Roccatagliatad ; lroccatagliata@neurologia.unige.it" class="auth_mail" title="E-mail the corresponding author ; Georg Northoffe ; f ; g ; h ; i ; georg.northoff@theroyal.ca" class="auth_mail" title="E-mail the corresponding author ; Matilde Inglesec ; d ; matilde.inglese@mssm.edu" class="auth_mail" title="E-mail the corresponding author ; Mario Amorea ; mario.amore@unige.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bipolar disorder ; White matter abnormalities ; DTI ; TBSS ; Bipolar phases ; Cognitive deficit
- 刊名：Journal of Affective Disorders
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：193
- 期：Complete
- 页码：39-50
- 全文大小：4145 K
文摘
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Bipolar patients show a widespread alteration in white matter (WM) structure.
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The global load of WM alterations increases from euthymia to mania and depression.
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Manic and depressed patients show different spatial patterns of WM alterations.
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The WM alterations are associated with cognitive deficits in bipolar patients.