Potential role of N-benzylcinnamide in inducing neuronal differentiation from human amniotic fluid mesenchymal stem cells
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- 作者：Wipawan Thangnipona ; wipawan.tha@mahidol.ac.th" class="auth_mail" title="E-mail the corresponding author ; Nicha Puangmalaia ; Nirut Suwannaa ; b ; Rungtip Soi-ampornkulc ; Ruchee Phonchaia ; Naiphinich Kotchabhakdia ; Sujira Mukdaa ; Tatsanee Phermthaid ; Suphakde Julavijitphongd ; Patoomratana Tuchindae ; Saksit Nobsathianf
- 关键词：Alzheimer&rsquo ; s disease ; N-Benzylcinnamide ; Differentiation ; Cholinergic neuron ; Antioxidant ; Mechanism
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：610
- 期：Complete
- 页码：6-12
- 全文大小：2642 K
文摘
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PT-3 in combination with BMP-9 elevated βIII-tubulin and ChAT expression in the differentiation process.
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PT-3 in combination with BMP-9 increased p53, but decreased Notch1 and SIRT1 levels.
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The effects of PT-3 in combination with BMP-9 may involve activation of ERK1/2 and PI3K/Akt.
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PT-3 may provide a useful adjuvant in BMP-9-induced transdifferentiation of AF-MSCs into ultimately cholinergic neurons.