RNA helicase Belle/DDX3 regulates transgene expression in Drosophila
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- 作者：Pang-Kuo Lo1 ; 2 ; Yi-Chun Huang1 ; John S. Poulton3 ; Nicholas Leake4 ; William H. Palmer5 ; Daniel Vera6 ; Gengqiang Xie ; Stephen Klusza3 ; Wu-Min Deng ; wumin@bio.fsu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Belle ; Transgene silencing ; Spindle-E ; Mod(mdg4) ; Dcr-1 ; piRNAs ; miRNA
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：412
- 期：1
- 页码：57-70
- 全文大小：6181 K
文摘
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Loss of Belle (Bel), a DEAD-box RNA helicase, induces transgene silencing.
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Spindle-E, Mod(mdg4) and Dcr-1 mediate transgene silencing in bel mutants.
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The balance between Spindle-E and Bel is vital to sustain the nuage integrity.
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Inhibition of Bel leads to the de novo generation of piRNAs from the transgene.