A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis
详细信息 查看全文
- 作者：Giuseppina Claps1 ; Yann Cheli1 ; Tongwu Zhang2 ; Marzia Scortegagna1 ; Eric Lau1 ; Hyungsoo Kim1 ; Jianfei Qi1 ; Jian-Liang Li1 ; Brian James1 ; Andreas Dzung3 ; Mitchell P. Levesque3 ; Reinhard Dummer3 ; Nicholas K. Hayward4 ; Marcus Bosenberg5 ; Kevin M. Brown2 ; Ze&rsquo ; ev A. Ronai1 ; zeev@ronailab.net" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：31 May 2016
- 年：2016
- 卷：15
- 期：9
- 页码：1884-1892
- 全文大小：5311 K
文摘
- •
Transcriptionally inactive ATF2 (Atf2Δ8,9) induces pigmentation
- •
Atf2Δ8,9 induces melanoma in BrafV600E mice
- •
Genes implicated in immune cell recruitment and metastasis are induced by Atf2Δ8,9
- •
Human ATF2 splice variant 5 phenocopies Atf2Δ8,9 and coincides with poor prognosis