Coronary Artery Dilation in Sickle Cell Disease

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• 作者：George T. Nicholson ; MD^a ; ^{gnichols@montefiore.org} ; Daphne T. Hsu ; MD^b ; Steven D. Colan ; MD^d ; Deepa Manwani ; MD^c ; William B. Burton ; PhD^e ; Darlene Fountain ; RN^b ; Leo Lopez ; MD^b
• 关键词：2D ; 2-dimensional ; BSA ; Body surface area ; CAE ; Coronary artery ectasia ; EDD ; Left ventricular end-diastolic dimension ; EDV ; Left ventricular end-diastolic volume ; EF ; Ejection fraction ; ESD ; Left ventricular end-systolic dimension ; Hct ; Hematocrit ; Hgb
• 刊名：The Journal of Pediatrics
• 出版年：2011
• 出版时间：November, 2011
• 年：2011
• 卷：159
• 期：5
• 页码：789-794.e2
• 全文大小：248 K

文摘

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Objective

To evaluate the prevalence of coronary artery dilation in children with sickle cell disease (SCD).

Study design

This is a retrospective analysis performed in patients, between 10 and 19 years old, with SCD who underwent a routine transthoracic echocardiographic evaluation over a 20-month period. The left main, left anterior descending, and proximal right coronary artery diameters, as well as clinical and laboratory variables and other echocardiographic results were collected. Echocardiographic measurements were converted to z scores by using information from a large control population of normal children. Coronary artery ectasia (CAE) was defined as a coronary artery diameter z score ¡Ý2. The patients with CAE were compared with those without CAE by using univariate and multivariate analyses.

Results

Seventeen of 96 patients with SCD (17.7 % ) had CAE. There were no differences in sex, age, height, weight, body surface area, or genotype between those with and those without CAE. Patients with CAE had larger left ventricular end-diastolic dimension, shortening fraction, septal thickness, posterior wall thickness, mass, mass-to-volume ratio, and white blood cell count. Multivariate analysis revealed that the mass-to-volume ratio and elevated white blood cell count were associated with CAE.

Conclusion

CAE is common in SCD and is associated with left ventricular hypertrophy and inflammation.