A novel nucleotide receptor in Xenopus activates the cAMP second messenger pathway

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• 作者：Christelle Devader ; Christian M. Drew ; Timothy J. Geach ; Jacqui Tabler ; Andrea Townsend-Nicholson ; Leslie Dale
• 关键词：P2Y₁₁ ; cAMP ; Calcium ; Embryo ; Xenopus
• 刊名：FEBS Letters
• 出版年：2007
• 出版时间：13 November 2007
• 年：2007
• 卷：581
• 期：27
• 页码：5332-5336
• 全文大小：694 K

文摘

We describe a Xenopus P2Y receptor that shares only weak homology with members of the mammalian P2Y family, being most similar to human P2Y₁₁. When activated by nucleotide analogs, it stimulates both calcium and cAMP mobilization pathways, a feature unique, among mammalian P2Y receptors, to P2Y₁₁. Activity can be blocked by compounds known to act as antagonists of mammalian P2Y₁₁. Genomic synteny between Xenopus and mammals suggests that the novel gene is a true ortholog of P2Y₁₁. Xenopus P2Y₁₁ is transcribed during embryonic development, beginning at gastrulation, and is enriched in the developing nervous system.