Anti-atherosclerotic effects of serelaxin in apolipoprotein E-deficient mice
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- 作者：Vedat Tiyerili ; 1 ; Vedat.Tiyerili@ukb.uni-bonn.de" class="auth_mail" title="E-mail the corresponding author ; Thomas Beiert1 ; Hannah Schatten ; Bakary Camara ; Julian Jehle ; Jan W. Schrickel ; Georg Nickenig ; René ; P. Andrié
- 关键词：Serelaxin ; Atherosclerosis ; Endothelial dysfunction
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：251
- 期：Complete
- 页码：430-437
- 全文大小：1272 K
文摘
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Serelaxin (SLX) has atheroprotective effects in the ApoE−/− model of atherosclerosis.
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SLX acts anti-inflammatory and inhibits atherosclecortic plaque development.
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SLX reduces oxidative stress and improves endothelial dysfunction.
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Angiotensin II receptor type 1a expression is downregulated by SLX.