The Th1/Th2 paradigm and the allograft response

详细信息    查看全文

• 作者：Strom ; Terry B ; Roy-Chaudhury ; Prabir ; Manfro ; Roberto ; Xheng ; Xin Xiao ; Nickerson ; Peter W ; et. al.
• 关键词：CTL cytotoxic T lymphocyte ; DST dnor-specific transfusion ; IFN interferon ; IL interleukin ; JAK Janus-associated kinase ; KO knockout ; mAb monoclonal antibody ; MST mean survival time ; R receptor ; STAT signal transducer and activator of transcription ; TCGF T
• 刊名：Current Opinion in Immunology
• 出版年：1996
• 出版时间：October, 1996
• 年：1996
• 卷：8
• 期：5
• 页码：688-693
• 全文大小：559 K

文摘

Although Th1- and Th2-type cytokine profiles have been associated with rejection and tolerance respectively, this paradigm may not be completely accurate. Instead, recent studies suggest that there could be a hierarchy of T-cell growth factors with regard to their ability to block tolerance and induce rejection (rather than a polarized Th1/Th2 demarcation).