Twelve-month and sixty-month outcomes of noncultured cellular grafting for vitiligo

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• 作者：Emily Yiping Gan ; MBBS(Honors) ; MRCP(UK) ; MMed(Int Med)^a ; Yan Ling Kong ; MBBS^a ; Wei Ding Tan ; MSc (Statistics)^a ; Steven T. Thng ; MBBS ; MRCP(UK) ; FRCP(Edin)^a ; Boon Kee Goh ; BSc(Hons) ; MBChB(UK) ; MRCP(UK) ; FRCP(Edin)^a ; ^b ; ^{gohboonkee@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：noncultured cellular grafting ; repigmentation ; vitiligo surgery
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：75
• 期：3
• 页码：564-571
• 全文大小：1495 K

文摘

Noncultured cellular grafting is a known surgical technique for vitiligo.

Objective

This study evaluated our center's 12-month repigmentation outcome and its maintenance up to 60 months, factors influencing repigmentation and safety data.

Methods

Clinicoepidemiologic and repigmentation data were reviewed for patients with vitiligo who had undergone noncultured cellular grafting from March 2006 to December 2012 at the National Skin Center, Singapore.

Results

All 177 patients who received noncultured cellular grafting during the study period were included. For those with available data, good to excellent repigmentation was present in 83% at 60 months. At 12 months, 88% of patients (n = 52) with segmental vitiligo achieved good to excellent repigmentation compared with 71% (n = 55) with nonsegmental vitiligo (P < .05). More patients on collagen dressings (82%) achieved good to excellent repigmentation compared with those who received hyaluronic acid (63%) (P < .05). Sites of lesions and postgrafting phototherapy did not significantly affect repigmentation outcome. Adverse reactions were uncommon and mild.

Limitations

The study is limited by its retrospective nature, the progressive loss to follow-up of patients, the absence of blinding, and the lack of use of standardized assessment tools.

Conclusion

Noncultured cellular grafting was successful in allowing more than 80% of patients to achieve good to excellent repigmentation for at least 60 months.