- 作者：Mari?lle P.K.J. Engelen ; Gulnur Com ; Robert R. Wolfe ; Nicolaas E.P. Deutz
- 关键词：BMI ; body mass index ; CF ; Cystic Fibrosis ; cTTR ; tracer&ndash ; tracee ratios of amino acids corrected for their baseline value ; DXA ; dual-energy X-ray absorptiometry ; EAA ; essential amino acids ; FEV1 ; forced expiratory volume in 1 ; s ; FFM ; fat-free mas
- 刊名：Journal of Cystic Fibrosis
- 出版年：2013
- 出版时间：September, 2013
- 年：2013
- 卷：12
- 期：5
- 页码：445-453
- 全文大小：526 K
Background
Current nutritional approaches have been partially successful in Cystic Fibrosis (CF). Essential amino acids mixtures with high Leucine levels (EAA) have anabolic properties in catabolic conditions, however data in CF are lacking.Methods
On two days according a randomized crossover design, 15 pediatric CF patients ingested 6.7 g EAA versus mixture of total amino acids as present in whey. Whole body protein and Arginine metabolism (as EAA lack Arginine) were assessed by stable isotope methodology.
Results
Protein synthesis (P < 0.05) but not protein breakdown was higher after EAA and 70 % higher values for net anabolism (P < 0.001)were found both in patients with and without nutritional failure. Arginine turnover was lower (P < 0.001) and de novo Arginine synthesis tended lower (P = 0.09) after EAA. Nitric oxide synthesis was not different.
Conclusions
CF patients are highly responsive to EAA intake independent of their nutritional status. Addition of Arginine to the EAA mixture may be warranted in CF.