The pathophysiological mechanisms of cognitive and behavioral disturbances in children with Landau–Kleffner syndrome or epilepsy with continuous spike-and-waves during slow-wave sleep

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• 作者：Lotte Nieuwenhuis ; Joost Nicolai
• 关键词：Epileptiform EEG discharges ; Cognition ; ESES ; CSWS ; Landau– ; Kleffner syndrome
• 刊名：Seizure
• 出版年：2006
• 出版时间：June 2006
• 年：2006
• 卷：15
• 期：4
• 页码：249-258
• 全文大小：163 K

文摘

Epilepsy with continuous spike- and -waves during slow-wave sleep and Landau–Kleffner syndrome are two rare childhood epilepsy syndromes. The underlying pathophysiology remains unknown. The current opinions about epidemiologic risk factors, genetic predisposition, EEG and MEG findings, influence of anti-epileptic drugs, neuroradiology, positron emission tomopgraphy, evoked potentials, auto-immunity and subpial transection are summarized.