Extracorporeal Life Support in a Case of Fatal Flecainide and Betaxolol Poisoning Allowing Successful Cardiac Allograft

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• 作者：Benoî ; t Vivien ; Nicolas Deye ; Bruno Mé ; garbane ; Jean-Sé ; bastien Marx ; Pascal Leprince ; Nicolas Bonnet ; France Roussin ; Laurent Jacob ; Alain Pavie ; Fré ; dé ; ric J. Baud ; Pierre Carli
• 刊名：Annals of Emergency Medicine
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：56
• 期：4
• 页码：409-412
• 全文大小：1062 K

文摘

Use of cardiac allograft for transplantation from donors after acute poisoning is a matter of debate because of potential toxic organ injuries, especially if death results from massive ingestion of cardiotoxic drugs. We report successful allograft cardiac transplantation from a brain-dead patient after severe flecainide and betaxolol self-poisoning requiring extracorporeal life support. Extracorporeal life support was initiated in the emergency department because of a refractory cardiac arrest caused by the cardiotoxicants' ingestion and continued after the onset of brain death to facilitate organ donation of the heart, liver, and kidneys. Forty-five months later, each organ recipient was alive, with normal graft function.