Sequence-Specific Sensing of Nucleic Acids

详细信息    查看全文

• 作者：Nicolas Vabret¹ ; ² ; ^{nicolas.vabret@mssm.edu} ; Nina Bhardwaj¹ ; Benjamin D. Greenbaum¹ ; ² ; ^{benjamin.greenbaum@mssm.edu}
• 关键词：innate immunity ; pattern recognition receptors ; RNA ; sequence patterns ; virus ; cancer
• 刊名：Trends in Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：38
• 期：1
• 页码：53-65
• 全文大小：2248 K
• 卷排序：38

文摘

Innate immune cells are endowed with many nucleic acid receptors, but the role of sequence in the detection of foreign organisms remains unclear. Can sequence patterns influence recognition? In addition, how can we infer those patterns from sequence data? Here, we detail recent computational and experimental evidence associated with sequence-specific sensing. We review the mechanisms underlying the detection and discrimination of foreign sequences from self. We also describe quantitative approaches used to infer the stimulatory capacity of a given pathogen nucleic acid species, and the influence of sequence-specific sensing on host–pathogen coevolution, including endogenous sequences of foreign origin. Finally, we speculate how further studies of sequence-specific sensing will be useful to improve vaccine design, gene therapy and cancer treatment.