Does COMT val158met polymorphism influence P50 sensory gating, eye tracking or saccadic inhibition dysfunctions in schizophrenia?

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• 作者：Caroline Demily^a ; ^{caroline.demily@ch-le-vinatier.fr} ; Sandrine Louchart-de-la-Chapelle^b ; ^{slouchart@chpg.mc} ; Irè ; ne Nkam^c ; ^{tatomdjap@gmail.com} ; Nicolas Ramoz^d ; ^{nicolas.ramoz@inserm.fr} ; Pierre Denise^e ; ^{pierre.denise@unicaen.fr} ; Alain Nicolas^f ; ^{alain.nicolas@ch-le-vinatier.fr} ; Caroline Savalle^g ; ^{savalle.caroline@voila.fr} ; Florence Thibaut^h ; ^{florence.thibaut@aphp.fr}
• 关键词：COMT gene polymorphism ; Schizophrenia ; Association studies ; Electrophysiology ; P50 auditory-evoked potential ; Endophenotypes ; Eye movements ; Smoking status
• 刊名：Psychiatry Research
• 出版年：2016
• 出版时间：30 December 2016
• 年：2016
• 卷：246
• 期：Complete
• 页码：738-744
• 全文大小：233 K
• 卷排序：246

文摘

Patients with schizophrenia show a higher rate of deficits measured by the SPEM, antisaccade and P50 inhibition paradigms. A higher accuracy of saccades during the predictive pursuit task associated is with the Met polymorphism in controls subjects. The COMT Val158Met polymorphism does not seem to be involved in these deficits observed in schizophrenia.