Synthesis of 3-substituted indolizidines from amino-ynones derivatives
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- 作者：Huy-Dinh Vua ; b ; Jacques Renaulta ; jacques.renault@univ-rennes1.fr" class="auth_mail" title="E-mail the corresponding author ; ; Thierry Roisnelc ; Nicolas Gouaulta ; Philippe Uriaca
- 关键词：Amino-ynone ; Indolizidine ; Methanesulfonic acid ; Zinc chloride
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：6 July 2016
- 年：2016
- 卷：57
- 期：27-28
- 页码：3036-3038
- 全文大小：759 K
文摘
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Indolizidine derivatives were efficiently obtained from amino-ynones.
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With methane sulfonic acid, amino-ynones furnished vinylogues of indolizidin-3-ones.
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In the presence of zinc chloride cyclization of amino-ynones produced stable enynes zinc complexes.
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Reduction of enynes zinc complexes produced 3-alkynyl indolizidines.