- 作者：Simona Ghetti ; Joshua K. Lee ; Clare E. Sims ; Dana M. DeMaster ; Nicole S. Glaser
- 刊名：The Journal of Pediatrics
- 出版年：2010
- 出版时间：January 2010
- 年：2010
- 卷：156
- 期：1
- 页码：109-114
- 全文大小：222 K
Objective
We tested the hypothesis that diabetic ketoacidosis (DKA) results in memory deficits typical of hypoxic/ischemic injury because recent studies suggest that cerebral metabolic changes similar to those observed in hypoxic/ischemic cerebral injury are observed in children with DKA, even without symptoms suggesting cerebral injury.Study design
Thirty-three children with type 1 diabetes mellitus (T1DM) and a history of DKA and 29 children with T1DM without a history of DKA were enrolled from an academic hospital pediatric endocrinology clinic. These groups were comparable on demographic and disease-related variables. These groups' ability to recall events in association with specific details, the memory function most directly affected by mild hypoxia/ischemia, was compared on 2 tasks (ie, event-color associations and event–spatial position associations).
Results
In multivariate analyses controlling for other critical variables, children with DKA history had significantly lower rates of accurate memory on both tasks (mean, 0.34 ± 0.13 on the color task and 0.57 ± 0.15 on the spatial task) than did children without DKA history (mean, 0.44 ± 0.11 and 0.65 ± 0.18, P < .01).
Conclusions
DKA disrupts memory function, underscoring the importance of DKA prevention when T1DM is known and prompt diagnosis of children with new onset of T1DM.