Plasma and exhaled breath condensate nitrite-nitrate level in relation to environmental exposures in adults in the EGEA study

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• 作者：Marta Rava ; Raph?elle Varraso ; Brigitte Decoster ; H¨¦l¨¨ne Huyvaert ; Nicole Le Moual ; B¨¦n¨¦dicte Jacquemin ; Nino K¨¹nzli ; Francine Kauffmann ; Farid Zerimech ; R¨¦gis Matran ; Rachel Nadif
• 关键词：CI ; confidence interval ; EBC ; exhaled breath condensate ; EGEA ; epidemiological study on genetics and environment of asthma ; FeNO ; fraction of exhaled nitric oxide ; NO ; nitric oxide ; ; nitrite ; ; nitrate ; NO2 ; nitrogen dioxide ; O3 ; ozone ; PM10 ; particulate
• 刊名：Nitric Oxide
• 出版年：2012
• 出版时间：15 October, 2012
• 年：2012
• 卷：27
• 期：3
• 页码：169-175
• 全文大小：217 K

文摘

This study evaluated the associations between biological markers in the nitrate-nitrite-NO pathway and four environmental exposures among subjects examined in the second survey (2003-2007) of the French Epidemiological study on Genetics and Environment of Asthma (EGEA). Total nitrite and nitrate ( /) levels were measured both in plasma and in exhaled breath condensate (EBC) in 949 adults. Smoking, diet and exposure to chlorine products were assessed using standardized questionnaires. Exposure to air pollutants was estimated by using geostatistical models. All estimates were obtained with generalized estimating equations for linear regression models. Median levels of / were 36.3 ¦ÌM (1st-3rd quartile: 25.7, 51.1) in plasma and 2.0 ¦Ìmol/mg proteins (1st-3rd quartile 0.9, 3.9) in EBC. After adjustment for asthma, age, sex and menopausal status, plasma / level increased with leafy vegetable consumption (above versus below median = 0.04 (95 % CI: 0.001, 0.07)) and decreased in smokers (versus non/ex-smokers = ?0.08 (95 % CI: ?0.11, ?0.04). EBC / level decreased in smokers (?0.08 (95 % CI: ?0.16, ?0.001)) and with exposure to ambient O₃ concentration (above versus below median = ?0.10 (95 % CI: ?0.17, ?0.03)). Cured meat, chlorine products, PM₁₀ and NO₂ concentrations were not associated with / levels. Results suggest that potential modifiable environmental and behavioral risk factors may modify / levels in plasma and EBC according to the route of exposure.