A simple physiologically based pharmacokinetic model evaluating the effect of anti-nicotine antibodies on nicotine disposition in the brains of rats and humans
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- 作者：Kyle Saylor saylor@vt.edu" class="auth_mail" title="E-mail the corresponding author ; Chenming Zhang ; chzhang2@vt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PBPK ; physiologically based pharmacokinetic model ; USD ; United States dollar ; CDC ; Centers for Disease Control and Prevention ; IC50 ; half maximal inhibitory concentration ; CMUNic ; 6-(carboxymethylureido)-(± ; )-nicotine
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：307
- 期：Complete
- 页码：150-164
- 全文大小：1499 K
文摘
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Modelling of nicotine disposition in the presence of anti-nicotine antibodies
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Key vaccine efficacy factors are evaluated in silico in rats and in humans.
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Model predicts insufficient antibody binding in past human nicotine vaccines.
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Improving immunogenicity and antibody specificity may lead to vaccine success.