The frequency of early-activated hapten-specific B cell subsets predicts the efficacy of vaccines for nicotine dependence
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- 作者：M. Laudenbacha ; A.M. Tuckera ; S.P. Runyonb ; F.I. Carrollb ; M. Pravetonia ; c ; prave001@umn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antigen-specific B cells ; Nicotine ; Addiction ; Vaccines ; Biomarkers
- 刊名：Vaccine
- 出版年：2015
- 出版时间：17 November 2015
- 年：2015
- 卷：33
- 期：46
- 页码：6332-6339
- 全文大小：741 K
文摘
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Two immunogens containing structurally-related nicotine haptens were compared in mice.
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Hapten-specific B cells were analyzed by antigen-based magnetic enrichment and flow cytometry.
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The most effective immunogen elicited more hapten-specific B cells shortly after immunization.
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Early frequency of hapten-specific B cells correlated with vaccine efficacy against nicotine.