Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors reverse ketamine-induced schizophrenia-like deficits in rats
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- 作者：Agnieszka Nikiforuk ; nikifor@if-pan.krakow.pl" class="auth_mail" title="E-mail the corresponding author ; Tomasz Kos ; Małgorzata Hołuj ; Agnieszka Potasiewicz ; Piotr Popik
- 关键词：Alpha 7 nicotinic acetylcholine receptors ; Positive allosteric modulators ; Schizophrenia ; Animal models ; Cognition ; Ketamine
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：389-400
- 全文大小：1625 K
文摘
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We evaluated the efficacies of α7-nAChRs PAMs in an animal model of schizophrenia.
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PNU-120596 and CCMI reversed ketamine-induced cognitive impairments.
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Both α7-nAChRs PAMs ameliorated ketamine-induced social interaction deficits.
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The efficacies of α7-nAChRs PAMs were comparable to those of A-582941.
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Galantamine also demonstrated procognitive, but not prosocial, efficacy.