Genetic knockout of the α7 nicotinic acetylcholine receptor gene alters hippocampal long-term potentiation in a background strain-dependent manner
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- 作者：Ronald K. Freunda ; Ron.Freund@UCDenver.edu" class="auth_mail" title="E-mail the corresponding author ; Sharon Grawc ; Kevin S. Chooc ; Karen E. Stevensc ; d ; Sherry Leonardc ; d ; Mark L. Dell&rsquo ; Acquaa ; b
- 关键词：aCSF ; artificial cerebrospinal fluid ; α7 nAChR ; alpha 7 nicotinic acetylcholine receptor ; CHRNA7 ; alpha 7 nicotinic acetylcholine receptor gene ; fEPSP ; field excitatory postsynaptic potential ; HFS ; high frequency stimulation ; Het ; heterozygous ; KO ; knockout ; LFS ; low-frequency stimulation ; LTD ; long-term depression ; LTP ; long-term potentiation ; PPR ; paired-pulse response ; TC ratio ; test-conditioning ratio ; WT ; wild-type
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：3 August 2016
- 年：2016
- 卷：627
- 期：Complete
- 页码：1-6
- 全文大小：1069 K
文摘
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Both α7nAChR function and genetic background are important in schizophrenia.
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C57/Bl6 and C3H mice differ in background expression of α7nAChRs (C3H > C57).
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Knockout of the α7nAChR gene impaired LTP in C3H but not C57 mice.
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C3H knockout mice displayed abnormal auditory gating, a schizophrenic phenotype.
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Genetic background strongly influences phenotypic expression in schizophrenia.