Calreticulin secures calcium-dependent nuclear pore competency required for cardiogenesis
详细信息 查看全文
- 作者：Randolph S. Faustinoa ; 1 ; Atta Behfara ; 1 ; Jody Groenendykc ; Saranya P. Wylesa ; Nicolas Niederlandera ; Santiago Reyesa ; Michel Puceatb ; Marek Michalakc ; Andre Terzica ; Carmen Perez-Terzica ; d ; e ; terzic.carmen@mayo.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Calreticulin ; Embryonic stem cells ; Nuclear transport ; Cardiac differentiation
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：63-74
- 全文大小：2440 K
文摘
- •
Calreticulin-deficient (crt−/−) embryonic stem cells (ESCs) exhibit nuclear flaws.
- •
Dysfunctional nuclear pore complex (NPC) remodeling occurs in crt−/− ESCs.
- •
Impaired nuclear import in crt−/− ESCs drives aberrant cardiogenesis.
- •
Rectified crt−/− ESC calcium dynamics corrects NPC, cardiophenotype abnormalities.
- •
Calcium-dependent crt-NPC signaling is a novel cardiac differentiation regulator.