abYsis: Integrated Antibody Sequence and Structure—Management, Analysis, and Prediction

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• 作者：Mark B. Swindells¹ ; Craig T. Porter² ; Matthew Couch² ; Jacob Hurst² ; ⁴ ; K.R. Abhinandan² ; ⁵ ; Jens H. Nielsen³ ; Gary Macindoe³ ; James Hetherington³ ; Andrew C.R. Martin² ; ^{andrew@bioinf.org.uk} ; ^{andrew.martin@ucl.ac.uk}
• 关键词：CDR ; complementarity-determining region ; PDB ; Protein Data Bank ; IMGT ; Immunogenetics Database ; EMBL-ENA ; European Molecular Biology Laboratory European Nucleotide Archive
• 刊名：Journal of Molecular Biology
• 出版年：2017
• 出版时间：3 February 2017
• 年：2017
• 卷：429
• 期：3
• 页码：356-364
• 全文大小：1302 K
• 卷排序：429

文摘

abYsis is a web-based antibody research system that integrates sequence data from EMBL-ENA and Kabat with sequence and structure data from the Protein Data Bank. It allows searches based on text, sequence data, and structural constraints. It automatically numbers sequences and provides detailed annotations to aid interpretation. Users can upload and analyze their own sequences in the same way via the web interface. It provides a comprehensive set of position and species-specific residue distributions. Additional advanced tools are provided to assess antibody characteristics such as humanness.