Neuronal gene repression in Niemann-Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway
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- 作者：Pablo S. Contrerasa ; b ; c ; 1 ; Marcelo Gonzalez-Zuñ ; igaa ; 1 ; Lila Gonzá ; lez-Hó ; darc ; Marí ; a José ; Yá ; ñ ; eza ; b ; c ; André ; s Dulceyd ; Juan Marugand ; Edward Setoe ; Alejandra R. Alvareza ; b ; aalvarez@bio.puc.cl" class="auth_mail" title="E-mail the corresponding author ; Silvana Zanlungoc ; f ; silvana@med.puc.cl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Niemann&ndash ; Pick type C disease ; Neuronal genes ; Histone deacetylase 2 ; Tyrosine kinase c-Abl ; Imatinib ; GNF2
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1859
- 期：2
- 页码：269-279
- 全文大小：1462 K
文摘
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HDAC2 levels are increased in NPC disease models.
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c-Abl inhibition prevents the increase of HDAC2 in NPC disease models.
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Cholesterol and oxidative stress are upstream regulators of the c-Abl/HDAC2 pathway.
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c-Abl inhibition prevents the HDAC2-dependent gene repression in NPC models.