Pore-forming toxins: Properties, diversity, and uses as tools to image sphingomyelin and ceramide phosphoethanolamine
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- 作者：Akiko Yamaji-Hasegawaa ; Franç ; oise Hullin-Matsudaa ; b ; Peter Greimela ; Toshihide Kobayashia ; b ; kobayasi@riken.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：AFM ; atomic force microscopy ; Chol ; cholesterol ; CPE ; ceramide phosphoethanolamine ; CTxB ; cholera toxin B subunit ; DOPC ; 1 ; 2-dioleoyl-sn-glycero-3-phosphocholine ; DPPC ; 1 ; 2-dipalmitoyl-sn-glycero-3-phosphocholine ; EM ; electron microscopy ; EqtII ; equinatoxin II ; EryA ; erylysin A ; ER ; endoplasmic reticulum ; IPC ; inositol phosphoceramide ; MβCD ; methyl-β-cyclodextrin ; MDCK ; Madin&ndash ; Darby canine kidney ; NPA ; Niemann Pick disease type A ; NT-lysenin ; non-toxic lysenin ; Oly ; ostreolysin ; PC ; phospha
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：1858
- 期：3
- 页码：576-592
- 全文大小：808 K
文摘
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Pore-forming toxins (PFTs) represent highly specific lipid-binding proteins.
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Non-toxic PFT derivatives are used to visualize lipids in live and fixed cells.
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Specific PFTs are applied to visualize sphingomyelin and ceramide phosphoethanolamine.
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PFTs revealed different pools of sphingomyelin in biological membranes.