Synthesis of CuO/graphene nanocomposites for nonenzymatic electrochemical glucose biosensor applications

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• 作者：Yu-Wei Hsu ; Ting-Kang Hsu ; Chia-Liang Sun ; Yung-Tang Nien ; Nen-Wen Pu ; Ming-Der Ger
• 关键词：Graphene ; Copper oxide ; Nanocomposite ; Nonenzymatic electrochemical biosensor ; Glucose
• 刊名：Electrochimica Acta
• 出版年：2012
• 出版时间：1 November, 2012
• 年：2012
• 卷：82
• 期：Complete
• 页码：152-157
• 全文大小：887 K

文摘

Glucose detection is of great importance in the fields of biological, environmental, and clinical analyses. In this study, CuO/graphene nanocomposites have been synthesized for nonenzymatic electrochemical glucose biosensors to avoid the disadvantages of enzymatic sensors. Transmission electron microscopy images show that the spherical and size-selected CuO nanoparticles were well dispersed on the surface of graphene. For the amperometric glucose detection, the low detection limit of 1 ¦Ìmol L^?1 with wide linear range from 1 ¦Ìmol L^?1 to 8 mmol L^?1 can be obtained using the CuO/graphene (CuOG)-modified glassy carbon (GC) electrode with a low loading. Under the applied potential of +0.60 V vs. Ag/AgCl, the optimal CuOG-modified GC electrode exhibits a sensitivity of 1065 ¦ÌA mmol^?1Lcm^?2. With such good analytical performance from simple process, it is believed that CuO/graphene nanocomposites are promising for the development of cost-effective nonenzymatic electrochemical glucose biosensors.