Relationship between placebo response rate and clinical trial outcome in bipolar depression
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- 作者：Nadia Iovienoa ; niovieno@partners.org" class="auth_mail" title="E-mail the corresponding author ; Andrew A. Nierenbergb ; c ; Susannah R. Parkinb ; Daniel Ju Hyung Kimb ; Rosemary S.W. Walkerb ; Maurizio Favaa ; b ; George I. Papakostasa ; b
- 关键词：Placebo response ; Bipolar depression ; Clinical trials
- 刊名：Journal of Psychiatric Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：38-44
- 全文大小：391 K
文摘
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We searched for RCTs of monotherapy oral drugs for bipolar depression.
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We investigated the impact of placebo response rates on the relative risk of response to drug versus placebo.
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Higher placebo response rates correlate with a lower risk ratio of response to drug versus placebo.
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Studies with placebo response rates >30% have a worse performance in showing a superiority of the drug versus placebo.
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Placebo response rates should be maintained below the threshold of 30%.