High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform
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- 作者：Gregory J. Nierode1 ; Brian C. Perea2 ; Sean K. McFarland3 ; Jorge F. Pascoal4 ; Douglas S. Clark2 ; David V. Schaffer2 ; 3 ; Jonathan S. Dordick1 ; dordick@rpi.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：high-content screening ; human neural stem cells ; high-throughput microarray ; screening ; neurotoxicity ; three-dimensional cell culture
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：8 November 2016
- 年：2016
- 卷：7
- 期：5
- 页码：970-982
- 全文大小：2558 K
文摘
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Demonstrated chip platform for HTS of protein expression and toxicity of 3D cultures
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Dose-response viability and proliferation of a 24-compound library on human NPC lines
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Assessed differential toxicity between progenitors and differentiating progeny
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Identified five compounds more toxic to undifferentiated progenitors